Edema & Weight Gain

weight gain caused by extra fluid in the body or an increase in body fat

weight gain: increase in entire body size (not only limbs), shortness of breath, clothing feels tighter. Edema: swollen hands, arms, legs, ankles, or feet. skin appears shiny and stretched, pitting (skin indents when you press it)

When do edema & weight gain start and how long do they last?

On average, edema begins 1.5 months after starting treatment, and lasts for 5 months. On average, weight gain begins 3.5 months after starting treatment and lasts for 2 years.

How serious is edema & weight gain?

The severity most often experienced is grade 1 or 2 but grade 3 or 4 are possible to experience.

How likely is it that I will experience edema & weight gain?

lorlatinib: 56% experience edema and 31% gain weight. Alectinib: 22% of people will experience edema. Crizotinib: 49% of people will experience edema.

Prevention Strategies

salt shaker with arrow down
black woman speed walking
scale to weigh yourself

Management Strategies

compression sock
black man with apple, heart, and weight
diuretic pill bottle with water drop on the front

Emergent Symptoms

If you are unsure, it is always safer to seek medical care.
Tell emergency staff you are on an ALK inhibitor for lung cancer.

phone

Call a Healthcare Provider

Call your care team

  • Fast weight gain

  • New or worse swelling in legs, feet, hands, or belly

  • Mild trouble breathing when moving

  • Peeing less than usual

  • Swelling that feels tight or uncomfortable

  • You feel more tired and have swelling

ambulance

Visit an Emergency Room

Call 911 or drive to your closest emergency room

  • Trouble breathing

  • Chest pain

  • Sudden swelling with pain or redness in one arm or leg

  • Swelling that quickly spreads up an arm or leg

  • Swelling of face, lips, tongue, or throat

  • Fast weight gain with very little pee

  • No pee at all